Hoodia contains an active ingredient, steroidal glycoside, that has been called “p57”. This p57 molecule increases hypothalamic ATP (adenosine triphosphate). Increased ATP triggers a message of satiety to your brain, eliminating the need to consume food in order to boost glucose levels, therefore preventing the desire to eat. Hoodia Gordonii is one of the most potent natural appetite regulators and doesn’t have the common side effects that most weight loss products have, such as indigestion, heart palpitations, bad moods, dizziness, headaches, stomach cramps and nausea. Clinical trials in the United Kingdom showed that Hoodia reduced food intake by about 1000 calories per day, compared to a placebo group, despite having unlimited access to food. In this clinical trial, the Hoodia subjects lost weight without feeling hungry. Subsequently, as the subjects ate less, so their stomachs shrunk and further weight loss was achievable. Effective weight management is directly linked to calorie intake, and Hoodia Gordonii can assist in achieve an optimum physique, eating plan and weight, all the while boosting energy. Dr Boxall’s Hoodia Tincture Drops are perfect for fast-acting, on-the-go support to eliminate food cravings. The perfect size to fit in a handbag or pocket, this product is a very convenient travel companion. This product can also be used to accompany the Dr Boxall’s Hoodia Veggie Capsule or Dr Boxall’s Green Coffee Bean products, for comprehensive assistance in weight management. All hoodia used in our product is 100% Certified Authentic by Cape Nature.

Hoodia contains an active ingredient, steroidal glycoside, that has been called “p57”. This p57 molecule increases hypothalamic ATP (adenosine triphosphate). Increased ATP triggers a message of satiety to your brain, eliminating the need to consume food in order to boost glucose levels, therefore preventing the desire to eat. Hoodia Gordonii is one of the most potent natural appetite regulators and doesn’t have the common side effects that most weight loss products have, such as indigestion, heart palpitations, bad moods, dizziness, headaches, stomach cramps and nausea. Clinical trials in the United Kingdom showed that Hoodia reduced food intake by about 1000 calories per day, compared to a placebo group, despite having unlimited access to food. In this clinical trial, the Hoodia subjects lost weight without feeling hungry. Subsequently, as the subjects ate less, so their stomachs shrunk and further weight loss was achievable. Effective weight management is directly linked to calorie intake, and Hoodia Gordonii can assist in achieve an optimum physique, eating plan and weight, all the while boosting energy. Dr Boxall’s Hoodia Tincture Drops are perfect for fast-acting, on-the-go support to eliminate food cravings. The perfect size to fit in a handbag or pocket, this product is a very convenient travel companion. This product can also be used to accompany the Dr Boxall’s Hoodia Veggie Capsule or Dr Boxall’s Green Coffee Bean products, for comprehensive assistance in weight management. All hoodia used in our product is 100% Certified Authentic by Cape Nature.

Green Coffee Bean Extract: Chlorogenic acid is a natural compound found in raw green coffee beans. When coffee beans are roasted, the chlorogenic acid is mostly destroyed, so any weight loss benefit from drinking regular coffee (i.e. coffee brewed from roasted coffee beans) would be mostly non-existent. Chlorogenic acid has been specifically shown to inhibit an enzyme, glucose6-phosphatase, which promotes the formation of glucose (sugar) in the liver. Hence, chlorogenic acid in coffee may be responsible, at least in part, for the reduced risk of glycemic disorders, such as diabetes. Chlorogenic acid inhibits the release of glucose into the blood stream, by slowing down the absorption of glucose in the blood stream. The chlorogenic acid ultimately results in a reduction in the absorption of fat. Various studies have shown that chlorogenic acid slows absorption of fat from food intake and also activates metabolism of extra fat. Unfortunately, traditional brewed coffee doesn’t serve as a good source of chlorogenic acid. Roasting green coffee beans removes its naturally bitter taste, but also removes a significant portion of chlorogenic acid. Hence, green coffee beans remain one of the best natural sources. In a study on green coffee bean, published in the Diabetes, Metabolic Syndrome and Obesity Journal, researchers followed a group of 16 adults who supplemented with a special green coffee bean extract of chlorogenic acids at different dosages (either 700 or 1050 milligrams per day) for 12 weeks. All 16 adults were considered overweight, as demonstrated by a BMI of greater than 25 (a normal BMI is between 18.5 and 25). The extract the researchers used contained an ingredient called GCA, which contains a standard green coffee extract of total chlorogenic acids and other hydroxycinnamic acids that have been known to have antioxidant health benefits. The subjects lost an average of 8kg. This was 10% of their overall body weight and 4.4% of their overall body fat. Recent chlorogenic acid research was discussed by Dr. Vinson in a presentation at the 245th National Meeting & Exposition of the American Chemical Society (ACS), the world’s largest scientific society. Vinson discussed the potential of natural substances extracted from unroasted coffee beans to help control the elevated blood sugar levels and body weight which underpin type 2 diabetes. His presentation focused on chlorogenic acids. He pointed out that type 2 diabetes, the most common form of diabetes, is an increasing global health problem, with almost 26 million patients in the United States alone. Vinson said, “A simple natural pill or capsule that would both help control blood sugar and foster weight loss at the same time, would be a major advance in the treatment of type 2 diabetes,” He added, “Our own research and studies published by other scientists suggest that such a treatment may, indeed, exist. There is significant epidemiological and other evidence that coffee consumption reduces the risk of type 2 diabetes.” Vinson said “One large study indicated a 50 percent risk reduction for people who drank seven cups of coffee a day compared to those who drank only two cups a day. I am trying to make the coffee and diabetes story as clear as possible for the public. The evidence points to chlorogenic acids as the active ingredients in coffee that both prevent diabetes and improve glucose control in normal, pre-diabetic and diabetic people.”

Green Coffee Bean Extract: Chlorogenic acid is a natural compound found in raw green coffee beans. When coffee beans are roasted, the chlorogenic acid is mostly destroyed, so any weight loss benefit from drinking regular coffee (i.e. coffee brewed from roasted coffee beans) would be mostly non-existent. Chlorogenic acid has been specifically shown to inhibit an enzyme, glucose6-phosphatase, which promotes the formation of glucose (sugar) in the liver. Hence, chlorogenic acid in coffee may be responsible, at least in part, for the reduced risk of glycemic disorders, such as diabetes. Chlorogenic acid inhibits the release of glucose into the blood stream, by slowing down the absorption of glucose in the blood stream. The chlorogenic acid ultimately results in a reduction in the absorption of fat. Various studies have shown that chlorogenic acid slows absorption of fat from food intake and also activates metabolism of extra fat. Unfortunately, traditional brewed coffee doesn’t serve as a good source of chlorogenic acid. Roasting green coffee beans removes its naturally bitter taste, but also removes a significant portion of chlorogenic acid. Hence, green coffee beans remain one of the best natural sources. In a study on green coffee bean, published in the Diabetes, Metabolic Syndrome and Obesity Journal, researchers followed a group of 16 adults who supplemented with a special green coffee bean extract of chlorogenic acids at different dosages (either 700 or 1050 milligrams per day) for 12 weeks. All 16 adults were considered overweight, as demonstrated by a BMI of greater than 25 (a normal BMI is between 18.5 and 25). The extract the researchers used contained an ingredient called GCA, which contains a standard green coffee extract of total chlorogenic acids and other hydroxycinnamic acids that have been known to have antioxidant health benefits. The subjects lost an average of 8kg. This was 10% of their overall body weight and 4.4% of their overall body fat. Recent chlorogenic acid research was discussed by Dr. Vinson in a presentation at the 245th National Meeting & Exposition of the American Chemical Society (ACS), the world’s largest scientific society. Vinson discussed the potential of natural substances extracted from unroasted coffee beans to help control the elevated blood sugar levels and body weight which underpin type 2 diabetes. His presentation focused on chlorogenic acids. He pointed out that type 2 diabetes, the most common form of diabetes, is an increasing global health problem, with almost 26 million patients in the United States alone. Vinson said, “A simple natural pill or capsule that would both help control blood sugar and foster weight loss at the same time, would be a major advance in the treatment of type 2 diabetes,” He added, “Our own research and studies published by other scientists suggest that such a treatment may, indeed, exist. There is significant epidemiological and other evidence that coffee consumption reduces the risk of type 2 diabetes.” Vinson said “One large study indicated a 50 percent risk reduction for people who drank seven cups of coffee a day compared to those who drank only two cups a day. I am trying to make the coffee and diabetes story as clear as possible for the public. The evidence points to chlorogenic acids as the active ingredients in coffee that both prevent diabetes and improve glucose control in normal, pre-diabetic and diabetic people.”

Sutherlandia contains a wide range of molecules that could explain the plant’s efficacy: 1) Canavanine is a potent non-protein amino acid and an L-arginine antagonist with documented antiviral, (including influenza virus and retroviruses) , antibacterial, antifungal and anticancer properties. L-canavanine is also a selective inhibitor of inducible nitric oxide synthase and therefore has application in the treatment of septic shock and chronic inflammation. 2) Pinitol is a known anti-diabetic agent, and has new quantitative research reflecting that it may also have clinical application in treating the wasting in cancer and AIDS patients. 3) GABA is an inhibitory neurotransmitter, which accounts for the relief from anxiety and stress and the improvement in mood and well-being experienced by many patients. 4) A novel triterpenoid glucoside has been isolated and characterized, which explains the positive effect Sutherlandia has on the immune system. Olive Leaf Extract: The primary medical constituents contained in unprocessed olive leaf are the antioxidants oleuropein and hydroxytyrosol, as well as several other polyphenols and flavonoids, including oleocanthal. Oleuropein is a natural broadspectrum antibiotic, antibacterial, antiviral and antifungal compound. Unlike synthetic antibiotics, it destroys only the harmful bacteria and protects the good. Medical research suggests that oleuropein searches out and “deactivates” the bacteria by dissolving the outer lining of the infectious germs and then penetrating the infected cells, thus inhibiting the replication of the bacteria. Two natural enzymes in the body, beta-esterase and beta-glucosidase, convert oleuropein to elolenic acid, which strengthens the immune system.

Olive leaf is used as a natural pathogen killer by inhibiting the replication process. As with bacteria, it has shown the ability to penetrate infected cells and stop viral replication directly. In the case of retroviruses, it is able to neutralize the production of reverse transcriptase and protease. These enzymes are essential for a retrovirus, such as HIV, to alter the RNA of a healthy cell. Olive leaf is also beneficial for the heart and has been shown to reduce low-density lipoproteins (LDL), or bad cholesterol and has been found to lower blood pressure and increase blood flow by relaxing the arteries. Olive leaf displays significant antioxidant properties that help protect the body from the continuous activity of free radicals. Free radicals are highly reactive chemical substances that, when oxidized, can cause cellular damage. Some recent research on olive leaf has shown its antioxidants to be effective in complimenting the treatment of some tumours and cancers such as liver, prostate and breast cancer.

Graviola has a long, rich history of use in herbal medicine as well as lengthy recorded traditional use. All parts of the graviola tree are used in natural medicine in the tropics, including the bark, leaves, roots, fruit, and fruit seeds. Different properties and uses are attributed to the different parts of the tree. Generally, the fruit and fruit juice are taken for worms and parasites, to cool fevers, to increase mother’s milk production after childbirth, and as an astringent for diarrhoea and dysentery. The crushed seeds are used to treat internal and external parasites, head lice, and worms. The bark, leaves, and roots are considered to have sedative, antispasmodic, hypotensive, and nervine, properties and a tea is often used to relieve these disorders. An “in vitro” research study at Purdue University’s School of Pharmacy and Pharmaceutical Sciences, found the active ingredients of the tree to be potent inhibitors of cancer cells, while leaving the normal cells alone. They also found the compounds to be potentially effective against drug-resistant cancer cells. In a 1976 plant screening program by the National Cancer Institute, graviola leaves and stem showed active toxicity against cancer cells and researchers have been following up on these findings since. Thus far, specific acetogenins in graviola and extracts of graviola have been reported to be selectively toxic in-vitro to these following types of tumor cells: lung carcinoma cell lines, human breast solid tumor lines, prostate adenocarcinoma, pancreatic carcinoma cell lines, colon adenocarcinoma cell lines, liver cancer cell lines, human lymphoma cell lines and multi-drug resistant human breast adenocarcinoma. Researchers in Taiwan reported in 2003 that the main graviola acetogenin, annonacin, was highly toxic to ovarian, cervical, breast, bladder and skin cancer cell lines at very low dosages saying; “. . . annonacin is a promising anti-cancer agent and worthy of further animal studies and, we would hope, clinical trials.”. An interesting in-vitro study was published in March of 2002 by researchers in Japan, observing various acetogenins found in several species of plants. In this study, some cancerous cells were exposed to a chemotherapy drug and the rest to the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). After two weeks, it was observed that the graviola acetogenin had an equally positive effect on the cells, but without the level of toxicity related to the chemotherapy drug. This led the researchers to summarize; “This suggested that annonacin was less toxic in mice. On considering the anti-tumor activity and toxicity, annonacin might be used as a lead to develop a potential anti-cancer agent.”

Sceletium Tortuosum is revered for its mood-enhancing effect, increasing alertness which gently fades into calmness, offering relief from tension, stress and anxiety. The mood-elevating action of Sceletium is caused by a number of alkaloids including mesembrine, mesembrenol and tortuosamine. These interact with the brain’s dopamine and serotonin receptors, also known as neurotransmitters, as a potent serotonin-uptake inhibitor. As a serotonin–uptake inhibitor, the brain is made proficient in reclaiming neurotransmitters from the neuron receptors to the originating nerves, thus keeping more serotonin in circulation. Sceletium is known to have a balancing effect on other feel-good neurotransmitters like dopamine, norepinephrine, and on adrenaline. Thus, mesembrine allows the brain to function with reduced levels of serotonin, allowing time for natural levels to build up. Sceletium is non- addictive, non hallucinogenic, and no severe adverse effects have been documented.

Sceletium Tortuosum is revered for its mood-enhancing effect, increasing alertness which gently fades into calmness, offering relief from tension, stress and anxiety. The mood-elevating action of Sceletium is caused by a number of alkaloids including mesembrine, mesembrenol and tortuosamine. These interact with the brain’s dopamine and serotonin receptors, also known as neurotransmitters, as a potent serotonin-uptake inhibitor. As a serotonin–uptake inhibitor, the brain is made proficient in reclaiming neurotransmitters from the neuron receptors to the originating nerves, thus keeping more serotonin in circulation. Sceletium is known to have a balancing effect on other feel-good neurotransmitters like dopamine, norepinephrine, and on adrenaline. Thus, mesembrine allows the brain to function with reduced levels of serotonin, allowing time for natural levels to build up. Sceletium is non- addictive, non hallucinogenic, and no severe adverse effects have been documented. Avena Sativa helps improve overall mental fitness and supports cognitive performance during stressful situations. Avena sativa has been shown to positively affect the activity of brain enzymes, closely related to mental health and cognitive function in-vitro. Additionally, clinical studies have confirmed that Avena sativa specifically interacts with brain structures and neurotransmitters implicated in cognition, memory and motivation.

Avena sativa boasts a dual activity profile on MAO-B and PDE 4, thus displayed in its ability to promote a strengthening and balancing effect on the brain and mind. This can be used as preventative or supportive measures. MAO B is known to be responsible for metabolizing dopamine. The levels of this neurotransmitter in the brain are essential for the regulation of mental and cognitive function. Inhibitors of MAO-B are employed for the treatment of neurodegenerative disorders, such as Parkinson’s and Alzheimer’s disease. The inhibition of MAO-B is associated with stimulative, mood enhancing and potentially neuro-protective properties. PDE 4, by contrast, is responsible for the degradation of the key second messenger cAMP (cyclic adenosine mono-phosphate). cAMP is involved in intra-cellular signal transduction, such as transferring the effects of neurotransmitters such as noradrenalin. PDE 4 inhibitors increase cAMP levels in the brain. Avena sativa is rich in nutrients such as silicon, manganese, zinc, calcium, phosphorus and Vitamins A, B1, B2 and E. Avena sativa alkaloids are believed to account for a relaxing effect. The beta-glucan found in Avena sativa may be helpful in lowering triglycerides.

Dr. Boxall’s 3-in-1 blend is designed to provide a holistic approach to brain health, offering a convenient way to incorporate these natural ingredients into your daily routine. Whether you’re looking to boost your cognitive performance, support memory recall, or simply maintain mental clarity as you age, this supplement offers a promising solution in a convenient 60-capsule package. Consider adding it to your regimen to promote optimal brain function and overall well-being.

Each 2 Veg Capsule Serving: 500mg Lion’s Mane Mushroom 10:1 300mg Bacopa Monnieri Extract 20% 200mg Gingko Biloba 50:1 Extract (24%/6%)

Sceletium Tortuosum is revered for its mood-enhancing effect, increasing alertness which gently fades into calmness, offering relief from tension, stress and anxiety. The mood-elevating action of Sceletium is caused by a number of alkaloids including mesembrine, mesembrenol and tortuosamine. These interact with the brain’s dopamine and serotonin receptors, also known as neurotransmitters, as a potent serotonin-uptake inhibitor. As a serotonin–uptake inhibitor, the brain is made proficient in reclaiming neurotransmitters from the neuron receptors to the originating nerves, thus keeping more serotonin in circulation. Sceletium is known to have a balancing effect on other feel-good neurotransmitters like dopamine, norepinephrine, and on adrenaline. Thus, mesembrine allows the brain to function with reduced levels of serotonin, allowing time for natural levels to build up. Sceletium is non- addictive, non hallucinogenic, and no severe adverse effects have been documented.

Moringa Leaf is regarded as one of nature’s most abundant sources of vitamins, minerals, and amino acids. Containing antioxidants such as flavonoids, polyphenols, and ascorbic acid, which fight free radicals or molecules that cause oxidative stress, cell damage, and inflammation. It reduces lipid and glucose levels, regulating oxidative stress in diabetic patients, normalising blood sugar, and preventing the build-up of cholesterol. Recent trials have shown an increase in overall brain health and cognitive function due to its antioxidant and neuro-enhancing activities. Moringa’s high concentrations of polyphenols protect the liver against oxidation, toxicity, fibrosis, and damage, enhancing blood detoxification, bile production, fructose and fat metabolism, and processing of nutrients.

Lucuma supports digestive health, weight management, skin health, and blood sugar regulation. Its dietary fibre aids digestion and promotes regular bowel movements. With its low glycemic index and high fibre content, it helps manage weight and blood sugar levels. The fruit’s antioxidants contribute to healthier skin, while its delightful naturally sweet taste enhances its appeal as a beneficial addition to this product with natural hints of caramel, butterscotch, and maple, making it reminiscent of a creamy and rich custard.

The mood-elevating action of Sceletium is promoted by several alkaloids including Mesembrine, Mesembrenol and Tortuosamine. These alkaloids interact with the brain’s dopamine and serotonin receptors, also known as neurotransmitters, and act as a potent serotonin-uptake inhibitor enhancing the brains proficiency in reclaiming neurotransmitters from the neuron receptors to the originating nerves, thus keeping more serotonin in circulation. It is known to have a balancing effect on other feel-good neurotransmitters such as dopamine, norepinephrine, and adrenaline. Thus, Mesembrine allows the brain to function better during periods of reduced levels of serotonin, allowing time for natural levels to build up. It helps to significantly reduce stress and boost vitality, including physical, emotional, and mental recovery. It has also shown a significant increase in the libido in both men and women.

Sceletium Tortuosum is revered for its mood-enhancing effect, increasing alertness which gently fades into calmness, offering relief from tension, stress and anxiety. The mood-elevating action of Sceletium is caused by a number of alkaloids including mesembrine, mesembrenol and tortuosamine. These interact with the brain’s dopamine and serotonin receptors, also known as neurotransmitters, as a potent serotonin-uptake inhibitor. As a serotonin–uptake inhibitor, the brain is made proficient in reclaiming neurotransmitters from the neuron receptors to the originating nerves, thus keeping more serotonin in circulation. Sceletium is known to have a balancing effect on other feel-good neurotransmitters like dopamine, norepinephrine, and on adrenaline. Thus, mesembrine allows the brain to function with reduced levels of serotonin, allowing time for natural levels to build up. Sceletium is non- addictive, non hallucinogenic, and no severe adverse effects have been documented.